ABEC’s Custom Single Run (CSR) Bioreactors establish a new industry paradigm for single use implementation.

CSR Bioreactors are fully customizable to meet exact process, facility, and operating needs. In particular, the Bioreactor Containers can be of any size or aspect ratio, with custom-designed mixing and aeration for today's varied and demanding processes. ABEC has also focused on operability and long-term container supply issues to provide reliable, productive solutions for clinical and commercial biopharmaceutical manufacturing. In short, customers no longer need to compromise when implement single use.

CSR Bioreactor Features

Containers

• Sizes continuous from 50L to >2000L
• Custom aspect ratio’s
• Simplified loading/unloading schemes
• Product contact surfaces: USP Class VI polymers, 316L stainless steel
• Agitator Seal: John Crane Type 21
• Sterilization: Gamma irradiation

Mixing and Aeration

• Agitators: Custom per process requirements – Power input, impeller type/size, shaft size
• Spargers: Drilled hole or fritted
• Baffles integral to container housing; Number and size custom per process requirements

Instrumentation & Controls

• PLC or DCS Automation custom per GAMP
• Temperature control and ramping per process needs and facility constraints
• pH/DO Probes: Conventional, Disposable (future)

Customer Benefits

By bringing a custom approach to single use, and leveraging over 35 years of bioreactor design experience, ABEC customers can take the benefits of single use to a new level. Specific benefits over standardized “off-the-shelf” single use systems include:

• Reduced investment in process development, transfer, and scale up
• Optimized yield and production economics
• Reduced container long-term supply risk
• Improved productivity in a cGMP manufacturing environment