Technology Transfer and Scale-Up of a High-Density E. coli Fermentation from a 200 L Stainless Steel to a 1000 L Single-Use Fermenter
While biopharmaceutical CDMOs (Contract Development
and Manufacturing Organizations) have widely embraced
single-use technologies for mammalian cell culture,
their adoption for microbial fermentation applications
has been slow. In contrast to single-use bioreactors
that are available in volumes up to 6000 L, single-use
fermenters are mostly restricted to volumes up to 300 L,
with the ABEC single-use fermenter being the only one
available up to 1000 L.