De-Risking Scale and Delivering Confidence

ABEC’s Process Sciences group provides data-driven insight that helps biopharma manufacturers move forward with confidence. Through modeling, testing, and validation, we prove performance early—reducing scale-up risk, accelerating decisions, and ensuring that our systems perform as designed before they ever reach the floor.

Model. Test. Confirm. Perform.

ABEC Process Sciences models, tests, and confirms process performance across scales to ensure consistent results from bench through commercial production. Using computational fluid dynamics (CFD), finite element analysis (FEA), Design of Experiments (DoE), and empirical testing, we de-risk scale-up and technology transfer—helping you reach manufacturing readiness faster and with greater predictability.

PROVEN TO DELIVER

PROOF BEFORE PRODUCTION

ABEC Process Sciences Clarity

ABEC Process Sciences applies advanced modeling and experimental validation to demonstrate how a process will behave at scale—before capital is committed. This way, you gain clarity on performance, scalability, and operating windows as early as possible in the program lifecycle.

ABEC Process Sciences Data Support

All testing done by ABEC Process Sciences is performed using representative equipment, materials, and process conditions—ensuring that results translate directly into real-world operation, not theoretical models.

ABEC Process Sciences Scale Support

ABEC Process Sciences is tightly integrated with ABEC system design—all insights from modeling and testing directly inform equipment configuration, control strategies, and scale-up approaches—reducing future iterations and rework.

Portfolio Integrations for Process Sciences

Whether supporting Custom Single Run (CSR®), stainless-steel systems, Hybrid BioProcessing, or Advanced Therapy Bioreactor (ATB™) workflows, ABEC Process Sciences provides a common-proof framework that unifies the entire ABEC portfolio.

FULL LIFECYCLE SUPPORT

Upstream Process Capabilities

  • SU and SS bioreactors; SU fermenters
  • Shake flask and rocking motion bioreactor for seeding preparation
  • Animal cell culture and microbial fermentation
  • ISO-7 and ISO-8 for execution of critical processes
  • Single-use bioreactors up to 6000L
  • Single-use fermenters up to 1000L
  • Metabolic flux analysis at pilot/large-scale
  • Media spent analysis
  • Demonstration, conformation, and scale-up runs

CFD Capabilities

  • Blend time
  • Surface vortexing
  • Agitator power and impeller power numbers
  • Shear and energy dissipation
  • Flow fields
  • Bubble coalescence and destruction
  • Bubble size, distribution, and dwell time
  • Gas fluid mixing and velocity
  • Mass transfer kLa (local and overall)
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